5-arylpyrrole derivatives

Details 5-arylpyrrole derivatives 5-arylpyrrole derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/30 (2006.01) A61K 31/40 (2006.01) C07D 207/333 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2316953

Compounds represented by general formula (I) or salts thereof and anti- inflammatory agents and antitumor agents containing these compounds as the active ingredient, wherein R1 represents hydrogen or lower alkyl; R2 represents lower alkyl or (CH2)n1 COOH (wherein n1 is 1, 2 or 3); R3 represents hydrogen, halogeno, carboxy, etc.; R4 represents phenyl optionally having a specific substituent, dicyclic heteroaryl, phenylethynyl or lower alkynyl; and R5 represents lower alkyl, amino, etc.

L'invention concerne des composés représentés par la formule générale (I), ou des sels de ceux-ci, ainsi que des agents anti-inflammatoires et antitumoraux contenant ces composés comme principe actif. Dans ladite formule (I), R?1¿ représente hydrogène ou alkyle inférieur, R?2¿ représente alkyle inférieur ou (CH¿2?)¿n1? COOH (où n1 représente 1, 2 ou 3), R?3¿ représente hydrogène, halogéno, carboxy, etc., R?4¿ représente phényle présentant éventuellement un substituant spécifique, hétéroaryle bicyclique, phényléthynyle ou alkynyle inférieur, et R?5¿ représente alkyle inférieur, amino, etc.

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