5-arylsulfonyl indoles having 5-ht6 receptor affinity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/16 (2006.01) A61K 31/4045 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) C07D 209/14 (2006.01)

Patent

CA 2452743

The invention provides derivatives of 5-arylsulfonyl indole and 5-arylsulfonyl indoline compounds which may be in the form of pharmaceutical acceptable salts or compositions that are useful in treating central nervous system diseases such as anxiety and depression. The invention also includes intermediates and processes to make the compounds, isotopically-labeled forms of the compounds and the use of the isotopically labeled forms of the compounds to perform nuclear magnetic resonance imaging and positron emission tomography.

L'invention concerne des dérivés de composés 5-arylsulfonyl indole et 5-arylsulfonyl indoline représentés par la formule (I), sous forme de sels pharmaceutiquement acceptables ou de compositions utilisées dans le traitement de maladies du système nerveux central telles que l'anxiété et la dépression. Cette invention concerne également des produits intermédiaires et des procédés permettant de fabriquer ces composés, des formes marquées au niveau isotopique de ces composés ainsi que l'utilisation de ces formes marquées au niveau isotopique de ces composés pour l'imagerie par résonance magnétique nucléaire et la tomographie par émission de positrons.

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