5-asa derivatives having anti-inflammatory and antibiotic...

Details 5-asa derivatives having anti-inflammatory and antibiotic... 5-asa derivatives having anti-inflammatory and antibiotic...

C - Chemistry, Metallurgy

07

C

C07C 311/51 (2006.01) A61K 31/195 (2006.01) C07C 311/41 (2006.01)

Patent

CA 2421114

Compounds are disclosed represented by the following formula (I): where R1 is a substituted or unsubstituted phenyl group, and where Z is selected such that a compound, Z- R1-NH2, formed by cleavage of the azo bond is a non-absorbable antibiotic; or an ester or pharmacologically acceptable salt of the compound of formula (I). Compounds of the present invention may be utilized for the prophylaxis or treatment of various diseases including, but not limited to, intestinal diseases such as inflammatory bowel disease and/or traveler's diarrhea, liver diseases such as hepatic encephalopathy, and/or diseases treatable by a non--absorbable antibiotic. The disclosed compounds include: (see formula I)

La présente invention concerne des composés représentés par la formule (I) dans laquelle R?1¿ représente un groupe phényle substitué ou non substitué et Z est sélectionné de sorte qu'un composé, Z-R?1¿-NH¿2?, formé par la coupure de la liaison azo soit un antibiotique non absorbable; ou un ester ou un sel pharmacologiquement acceptable du composé de formule (I). Les composés selon l'invention peuvent être utilisés pour prévenir ou traiter diverses maladies telles que par exemple, les maladies intestinales telles que la maladie intestinale inflammatoire et/ou la diarrhée du voyageur, les maladies du foie telles que l'encéphalopathie hépatique et/ou les maladies pouvant être traitées par un antibiotique non absorbable. Formule (I)

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