5-benzyl barbiturate derivatives

Details 5-benzyl barbiturate derivatives 5-benzyl barbiturate derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/62 (2006.01) A61K 31/515 (2006.01)

Patent

CA 2080343

5-benzyl barbiturate compounds for use as water-soluble uridine phosphorylase inhibitors are disclosed. These compounds are useful for reducing the toxicity and anemia induced by antiviral drugs, such as AZT, as well as for potentiating anticancer drugs and combatting their host-toxicity. These compounds are represented by the general formula: Image where R1 = OCH3, and R2 = H, or an acyclotail of the general formula: Image where R3 = H, CH2OH, or CH2NH2, and R4 = OH, NH2, or OCOCH2CH2CO2H

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