5-benzyl substituted-benzimidazo-line-2-thion derivatives...

Details 5-benzyl substituted-benzimidazo-line-2-thion derivatives... 5-benzyl substituted-benzimidazo-line-2-thion derivatives...

C - Chemistry, Metallurgy

07

D

C07D 235/28 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2050948

NOVEL 5-BENZYL SUBSTITUTED-BENZIMIDAZOLINE 2-THION DERIVATIVES AND A PROCESS FOR PREPARING THE SAME A B S T R A C T The present invention relates to novel antihyperlipo- proteinemic 5-benzyl substituted benzimidazoline-2-thion derivatives of formula I Image (I) wherein X represents halogen atom, methyl, ethyl, methoxy or ethoxy group, Y stands for hydroxy if X is methoxy or ethoxy, otherwise it represents hydrogen atom, methoxy or ethoxy group; Z is methoxy or ethoxy group if X or Y represents methoxy group, ethoxy group, otherwise it is hydrogen atom, The invention also covers antiartheriosclerotic, anti- hyperlipoproteinemic pharmaceutical compositions, suitable for inhibiting the formation of thrombuses, comprising the compounds of formula I in an effective dose, a process for preparing the same and methods for the treatment of hyperlipo- proteinemia with the aid of the said compounds or compositions.

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