C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/21, 260/51
C07J 1/00 (2006.01) C07J 17/00 (2006.01) C07J 19/00 (2006.01) C07J 21/00 (2006.01) C07J 53/00 (2006.01) C07J 71/00 (2006.01)
Patent
CA 1156646
ABSTRACT OF THE DISCLOSURE The present invention provides a process for the pre- paration of a 5.beta.-hydroxy-.DELTA.6-steroid of the general formula Image in which R1 represents hydrogen, an acyl group, a low molecular weight alkyl group or the tetra-hydro-pyranyl group, R2 and R3 each represent hydrogen, or together represent the methylene group, and X stands for oxygen, or the group Image , Image , Image , Image , Image (wherein R4 is hydrogen or an acyl) group or Image wherein R5 is hydrogen or a low molecular weight alkyl group which comprises reacting the corresponding 7.alpha.-chloro-5.beta.,6.beta.-opoxy- steroids in an inert solvent, in the presence of metallic zinc, at temperatures between room temperature and 100°C, with a low molecular weight alaphstic carboxylic acid or dilute mineral acid. The process avoids the use of organo-selenium compounds The invention also provides novel 5.beta.-hydroxy-.DELTA.6-steroids.
384258
Bittler Dieter
Laurent Henry
Nickisch Klaus
Nickolson Robert
Wiechert Rudolf
Marks & Clerk
Schering Aktiengesellschaft
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