[5-carboxamido or 5-fluoro]-[2',3'-unsaturated or...

Details [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or... [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or...

A - Human Necessities

61

K

A61K 31/7068 (2006.01) A61K 31/52 (2006.01) A61K 38/21 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2211612

A method and composition for the treatment of HIV an HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]- 2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleoside or a [5- carboxamido or 5-fluoro]-3'-modified-pyrimidine nucleoside, mixtures thereof, or a pharmaceutically acceptable derivative or derivatives thereof, including an N-1 or N-4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

Procédé et composition pour traiter des infections à VIH et au virus de l'hépatite B chez des êtres humains et d'autres animaux hôtes. On administre une quantité efficace d'un nucléoside de [5-carboxamido ou 5-fluoro]-2'-3'-didésoxy-2',3'-didéhydro-pyrimidine ou d'un nucléoside de [5-carboxamido ou 5-fluoro]-pyrimidine modifié en 3', ou un mélange ou dérivé pharmaceutiquement acceptable de ceux-ci, y compris un dérivé alkylé ou acylé N1 ou N4, ou un sel pharmaceutiquement acceptable de ceux-ci, dans un excipient pharmaceutiquement acceptable.

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