C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/56 (2006.01) A61K 31/426 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07D 233/90 (2006.01) C07D 239/42 (2006.01) C07D 263/48 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2588517
The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y1, Y2, R1, n, R3, R8, R9, R10, L1, L2, Ar1 and Ar2 are defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
La présente invention concerne des composés qui interagissent avec des canaux ioniques. En particulier, l~invention concerne des composés ayant la formule structurelle (I), (II), (III) ou (IV), des stéréo-isomères, des tautomères, des racémiques, des promédicaments, des métabolites de ceux-ci, ou un sel pharmaceutiquement acceptable et/ou un solvate de ceux-ci, où X, Y1, Y2, R1, n, R3, R8, R9, R10, L1, L2, Ar1 et Ar2 sont définis dans la revendication 1. La présente invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et l~utilisation desdits composés dans des procédés de traitement des corps humain et animal.
Blom Petra
de Kerpel Jan Octaaf
Fourmaintraux Eric Pierre Paul Rene
Kaletta Titus Jan
Leysen Dirk
Devgen N.v.
Smart & Biggar
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