¬5-chloro-6-phenyl-2-(4-trifluoromethylphenyl)-4-pyrimidinyl...

Details ¬5-chloro-6-phenyl-2-(4-trifluoromethylphenyl)-4-pyrimidinyl... ¬5-chloro-6-phenyl-2-(4-trifluoromethylphenyl)-4-pyrimidinyl...

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2390259

5-Chloro-6-phenyl-2-(4-trifluoromethylphenyl)-4-pyrimidinylamino]acetamide derivatives represented by general formula (I). Because of having a potent antirheumatic effect and a low toxicity, these compounds are useful as remedies and preventives for rheumatic diseases such as rheumatism, Becet's disease and ankylosing spondylitis, and inflammatory immunologic diseases such as multiple screlosis, systemic lupus erythematosus and inflammatory autoimmunologic diseases such as Sjoegren's syndrome. In said formula, R1 represents methyl or cyclopropyl.

L'invention concerne des dérivés de [5-chloro-6-phényl-2-(4-trifluorométhylphényl)-4-pyrimidinylamino]acétamide représentés par la formule générale (I). Du fait de leur puissant effet antirhumatismal et de leur faible toxicité, ces composés peuvent être utilisés comme agents thérapeutiques ou comme agents de prévention contre les maladies rhumatismales telles que le rhumatisme, la maladie de Becet et la spondylarthrite ankylosante, et contre les maladies immunologiques inflammatoires telles que la sclérose en plaques, le lupus érythémateux disséminé et les maladies auto-immunes inflammatoires (syndrome de Sjögren, par exemple). Dans la formule générale (I), R?1¿ représente méthyle ou cyclopropyle.

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