5-cyano-1h-indole derivatives as antagonists of the...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/42 (2006.01) A61K 31/405 (2006.01) C07D 209/00 (2006.01) C07D 209/18 (2006.01) C07D 333/00 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2447184

The invention concerns 5-cyano-1H-indole derivatives of formula (I), wherein: R¿1?, R¿2?, X and n are such as defined in Claim 1, as well as their pharmaceutically acceptable salts, solvates, and hydrates. The invention also concerns pharmaceutical compositions containing them, and their use for preparing medicines for preventive or curative treatment of diseases mediated by the activation of the CXCR2 receptor of interleukine-8 and chemokines of the same family.

La présente invention concerne les dérivés de 5-cyano-1H-indole de formule (I): dans laquelle R1, R2, X et n sont tels que définis à la revendication 1, ainsi que leurs sels, solvats et hydrates pharmaceutiquement acceptables. L'invention a également pour objet les compositions pharmaceutiques les contenant, ainsi que leur utilisation pour la préparation de médicaments destinés au traitement préventif ou curatif des maladies dépendantes de l'activation du récepteur CXCR2 de l'interleukine-8 et des chimiokines de la même famille.

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