5'-dithio-modified oligonucleotides

Details 5'-dithio-modified oligonucleotides 5'-dithio-modified oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2195864

The present invention provides nuclease resistant 5'-dithio-modified oligonucleotides that are useful in nucleic acid therapeutics and diagnostics. The novel modified oligonucleotides have at least one 5'-dithioate linkage, wherein both the oxygen atom at the 5'-position (5'-bridging oxygen) and at least one of the non-bridging oxygen atoms of a naturally occurring phosphodiester linkage are independently replaced with a single sulfur atom. The invention also provides a polymer-supported method for making 5'-dithio- modified and 5'-thio-modified oligonucleotides as well as novel monomeric nucleoside and nucleotide intermediates useful in the synthetic method.

La présente invention concerne des oligonucléotides à modification 5'-dithio résistant aux nucléases et qui sont utiles dans les diagnostics et thérapies à base d'acide nucléique. Les nouveaux oligonucléotides modifiés présentent au moins une liaison 5'-dithioate dans laquelle, aussi bien l'atome d'oxygène en position 5' (oxygène pontant 5'), que l'un au moins des atomes d'oxygène non pontants d'une liaison phosphodiester survenant naturellement, sont remplacés indépendamment par un seul atome de soufre. L'invention concerne également un procédé à base de polymère permettant la production d'oligonucléotides à modification 5'-dithio et à modification 5'-thio, ainsi que des nouveaux intermédiaires de nucléosides et de nucléotides monomères utiles dans le procédé de synthèse.

Affiliated with

Also associated with

Rating

5'-dithio-modified oligonucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5'-dithio-modified oligonucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5'-dithio-modified oligonucleotides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1830073