5-endo-(3-indolecarbonyloxy)-n-(amino (lower alkyl)-bicyclo...

Details 5-endo-(3-indolecarbonyloxy)-n-(amino (lower alkyl)-bicyclo... 5-endo-(3-indolecarbonyloxy)-n-(amino (lower alkyl)-bicyclo...

C - Chemistry, Metallurgy

07

D

260/306.1

C07D 209/56 (2006.01) A61K 31/40 (2006.01) C07D 403/12 (2006.01)

Patent

CA 1068281

ANTI-ARRHYTHMIC AGENTS ABSTRACT OF THE DISCLOSURE This specification discloses a novel series of 5-endo- (3-indolecarbonyloxy)-N-[amino(lower)alkyl]-bicyclo[2.2.1] heptane-2,3-di-endo-carboxylic acid imides processing anti- arrhythmic and/or anti-fibrillatory activity. The mechanism of cardiac arrhythmia is suspected to be caused by an abnormal "focus" in the ventricle of the heart which sends out (fires) nerve signals more rapidly than required for the normal beat- ing of the heart. Uncontrolled arrhythmia can lead to fibril- lation which often results in death. It has been discovered that the above mentioned series of compounds are useful therapeutic or prophylactic agents in the supression of the abnormal ectopic beat. The present specification, therefore, discloses a compound having the formula I Image (I) wherein R7 is H or CH3; R1 is Cl, Br, F, H or (lower)alkyl; R2 and R3 are alike or different and each is H, Cl, Br, F, (lower) alkyl, nitro, CF3, OH or (lower)alkoxy; n is an integer of 2 to 4 inclusive; and R4 and R5 are alike or dif- ferent and each is H, (lower)alkyl or when taken together with the nitrogen a radical of the formula Image , Image , Image or Image in which R6 is (lower)alkyl; the dextro-or levo-rotatory isomer thereof, or a pharmaceutically acceptable acid addition salt of said compound I or said isomer thereof.

235093

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