5-h-benzo[d]naphth[2,1-b]azepine derivative as selective...

Details 5-h-benzo[d]naphth[2,1-b]azepine derivative as selective... 5-h-benzo[d]naphth[2,1-b]azepine derivative as selective...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) C07D 223/14 (2006.01) C07D 403/10 (2006.01) C07D 407/12 (2006.01)

Patent

CA 2526017

The present invention provides compounds of formula (I), which, are novel antagonists for D1/D5 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1/D5 receptor antagonists as well as methods of using them to treat CNS disorders, obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

L'invention concerne des composés qui sont de nouveaux antagonistes des récepteurs D¿1?/D¿5?, ainsi que des procédés de préparation associés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques contenant lesdits antagonistes des récepteurs D¿1?/D¿5?, ainsi que des méthodes d'utilisation de ces compositions dans le traitement des troubles du système nerveux central, de l'obésité, des troubles métaboliques, des troubles alimentaires, tels que l'hyperphagie, et du diabète.

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