C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/23 (2006.01) A61K 31/7042 (2006.01) A61P 31/04 (2006.01) A61P 33/02 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2496698
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5'-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
La présente invention concerne des composés représentés par la formule (I) qui sont des inhibiteurs des purine nucléoside phosphorylases (PNP), des purine phosphoribosyltransférases (PPRT), des 5'-méthylthioadénosine phosphorylases (MTAP), des 5'-methylthioadénosine nucléosidases (MTAN) et/ou des hydrolases de nucléoside (NH). Cette invention se rapporte également à l'utilisation de ces composés dans le traitement des maladies et des infections telles que le cancer, les infections bactériennes, les infections causées par des protozoaires et les maladies induites par les cellules T, ainsi que des compositions pharmaceutiques renfermant lesdits composés.
Evans Gary Brian
Furneaux Richard Hurbert
Lenz Dirk Henning
Schramm Vern L.
Tyler Peter Charles
Albert Einstein College Of Medicine Of Yeshiva University
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Industrial Research Limited
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