5-hetero-or aryl-substituted-imidazol¬2,1-a| isoquinolines

Details 5-hetero-or aryl-substituted-imidazol¬2,1-a| isoquinolines 5-hetero-or aryl-substituted-imidazol¬2,1-a| isoquinolines

C - Chemistry, Metallurgy

07

D

167/125, 167/211

C07D 471/04 (2006.01) A61K 31/395 (2006.01) A61K 31/47 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1317942

- 1 - Abstract Compounds of formula I Image I wherein each R independently is hydrogen or methyl, R1 is in 8- or 9-position and represents hydrogen, chloro, fluoro or C1-3alkyl and R2 represents thienyl, furyl or Image wherein each Ro represents independently hydrogen, fluoro, chloro, C1-10alkyl, C1-10alkoxy or C1-10alkylthio or one Ro is hydrogen and the other represents tri-(C1-3alkyl)silyl, trifluoromethyl, phenyl, monochlorophenyl, monofluorophenyl, Image wherein X, Y, R3, R3' or R4 are as defined herein or two Ro's on adjacent carbon atoms form methylenedioxy. The compounds are indicated for use in treating PAF-mediated bronchocontriction and extravasation and in part in treating tumors.

542087

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