5-heteroaryl substituted indoles

Details 5-heteroaryl substituted indoles 5-heteroaryl substituted indoles

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61P 25/18 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2477074

The present invention relates 5-heteroaryl substituted indoles having high affinity for .alpha.~1-adrenoceptors. Accordingly, the compounds of the invention are considered useful for the treatment of diseases or disorders responsive to .alpha.~1-adrenoceptor antagonists. Further, as some of the compounds are selective .alpha.~1-adrenoceptor ligands they may be particularly useful as PET or SPECT ligands.

L'invention concerne des indoles à substitution 5-hétéroaryle possédant une affinité importante pour les récepteurs adrénergiques alpha 1. De ce fait, ces composés sont considérés utiles pour traiter des troubles ou des maladies sensibles aux antagonistes du récepteur adrénergique alpha 1. Etant donné, également, que quelques uns de ces composés sont des ligands sélectifs du récepteur adrénergique alpha 1, ils peuvent être particulièrement utiles en tant que ligands de PET ou CPECT.

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