5-heteroaryl thiazoles and their use as p13k inhibitors

Details 5-heteroaryl thiazoles and their use as p13k inhibitors 5-heteroaryl thiazoles and their use as p13k inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2585310

The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.

L~invention concerne des dérivés de thiazole de formule (I), ou leurs sels de qualité pharmaceutique, dans lesquels le cycle A, R1, R2 et R3 sont tels que définis dans la description de l~invention. Sont également décrits des procédés pour fabriquer lesdits dérivés, des compositions pharmaceutiques qui les contiennent et leur utilisation thérapeutique, par exemple pour traiter la maladie causée par une enzyme PI3K et/ou une mTOR kinase.

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