5-heteroatom-substituted pyrazoles

Details 5-heteroatom-substituted pyrazoles 5-heteroatom-substituted pyrazoles

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/53 (2006.01) C07D 401/04 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2411011

The present invention relates to 5-heteroatom- substituted pyrazoles of the formula I: Image wherein the ring of the formula (R 5)-A-(SO m R 4) is a substituted phenyl, pyridinyl, pyrimidinyl, pyridazinyl or triazinyl; m is 0, 1 or 2; B is -O-, -S-, -SO-, -SO2- or R 6-N-; R 1 is H, nitro, cyano, alkyl, substituted sulfonyl, formyl, ketone, ester or amino; R 2 is H, nitro, cyano, hydrocarbon, heterocyclyl, heteroaryl, alkoxy, cycloalkoxy, aryloxy, heteroaryloxy, heterocyclyloxy, formyl, ketone, ester, amino, amide or alkylthio; R 3 is optionally substituted alkyl, aryl, cycloalkyl, heteroaryl or heterocyclyl; R 4 is substituted amide, amino or imide; R 5 is H, halo, hydroxy, alkoxy, hydrocarbon, formyl, ketone, ester, amide, amino or alkylthio; and R 6 is H, hydrocarbon, heteroaryl or heterocyclyl, The present invention also relates to pharmaceutical compositions containing compounds of formula I and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

Affiliated with

Also associated with

Rating

5-heteroatom-substituted pyrazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-heteroatom-substituted pyrazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-heteroatom-substituted pyrazoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1416681