C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/08 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 209/30 (2006.01) C07D 403/06 (2006.01)
Patent
CA 2670717
The present invention relates to novel 5-(Heterocyclyl)alkyl-N- (arylsulfonyl)indole compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.
La présente invention concerne de nouveaux composés 5-(hétérocyclyl)alkyl-N-(arylsulfonyl)indole de formule (I), leurs dérivés, leurs stéréo-isomères, leurs sels pharmaceutiquement acceptables et des compositions pharmaceutiquement acceptables les contenant. La présente invention concerne également un procédé de préparation desdits nouveaux composés ci-dessus, de leurs dérivés, de leurs stéréo-isomères, de leurs sels pharmaceutiquement acceptables et des compositions pharmaceutiquement acceptables les contenant. Ces composés sont utiles dans le traitement de divers troubles associés aux fonctions du récepteur 5-HT6. Spécifiquement, les composés de la présente invention sont également utiles dans le traitement de divers troubles du SNC, troubles hématologiques, troubles alimentaires, maladies associées à une douleur, maladies respiratoires, troubles uro-génitaux, maladies cardiovasculaires et cancer.
Jasti Venkateswarlu
Kambhampati Rama Sastri
Konda Jagadishbabu
Kothmirkar Prabhakar
Ramakrishna Nirogi Venkata Satya
Blake Cassels & Graydon Llp
Suven Life Sciences Limited
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