A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4523 (2006.01) A61K 31/4525 (2006.01) A61K 31/453 (2006.01) A61K 31/454 (2006.01) A61K 31/46 (2006.01) A61K 31/5365 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01)
Patent
CA 2750796
The invention relates generally to the treatment of diseases of the respiratory system such as asthma and chronic obstructive pulmonary disease. More particularly, the present invention relates to methods of treating and preventing asthmatic airway inflammation. The treatment involves the administration of a 5-HT4 receptor antagonist to the subject in need thereof; more in particular the administration of aroylated 4-aminomethylpiperidine derivatives as defined herein. Other aspects of the invention are directed to compositions for treating or preventing respiratory disorders, including pharmaceutical compositions.
L'invention porte d'une manière générale sur le traitement de maladies du système respiratoire telles que l'asthme et la maladie pulmonaire obstructive chronique. Plus particulièrement, la présente invention porte sur des procédés de traitement et de prévention d'une inflammation asthmatique des voies aériennes. Le traitement met en jeu l'administration d'un antagoniste du récepteur 5-HT4 au sujet en ayant besoin; plus particulièrement, l'administration de dérivés de 4-aminométhylpipéridine aroylé tels que ceux définis ici. D'autres aspects de l'invention portent sur des compositions de traitement ou de prévention des troubles respiratoires, comprenant des compositions pharmaceutiques.
de Maeyer Joris
Meulemans Ann
Schuurkes Jan
Thielemans Leen
Shire-Movetis N.v.
Sim & Mcburney
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