5-ht4 receptor antagonists for the treatment of heart failure

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/5365 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2485600

This invention provides the use of a 5-HT4 receptor antagonist in the manufacture of a medicament for treating or preventing heart failure. Particular heart disorders to be treated are selected from the group comprising chronic heart failure, congestive heart failure, chronic congestive heart failure and heart failure resulting from ischaemic heart disease. Methods of treating heart failure using 5-HT4 receptor antagonists and pharmaceutical compositions containing 5-HT4 receptor antagonists are also provided.

L'invention concerne l'utilisation d'un antagoniste du récepteur 5-HT¿4? pour la préparation d'un médicament destiné au traitement et à la prévention de l'insuffisance cardiaque. Les troubles cardiaques spécifiques à traiter sont sélectionnés dans le groupe comprenant l'insuffisance cardiaque chronique, l'insuffisance cardiaque congestive, l'insuffisance cardiaque congestive chronique et l'insuffisance cardiaque résultant d'une cardiopathie ischémique. L'invention concerne également des méthodes de traitement de l'insuffisance cardiaque, comprenant l'administration d'antagonistes du récepteur 5-HT¿4,? et des composition pharmaceutiques contenant des antagonistes du récepteur 5-HT¿4?.

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