5-ht7 receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/06 (2006.01) A61K 31/47 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2590666

The invention relates to compounds of formula (I) having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5- HT is involved, such as CNS disorders.

L'invention concerne des composés de formule (I) présentant une activité pharmacologique envers le récepteur 5-HT7, et plus particulièrement certains composés sulfonamide substitués par une tétrahydroisoquinoléine. L'invention décrit également des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant, et leur utilisation pour le traitement et/ou la prophylaxie d'une maladie dans laquelle 5-HT est impliquée, telle que les troubles du système nerveux central.

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