5-ht7 receptor antagonists

Details 5-ht7 receptor antagonists 5-ht7 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 217/04 (2006.01) A61K 31/47 (2006.01) A61K 31/4725 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2575771

The invention relates to compounds of formula (I) having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5- HT is involved, such as CNS disorders.

L'invention concerne des composés de formule (I), présentant une activité pharmacologique par rapport au récepteur 5-HT7, et plus particulièrement par rapport à certains composés de sulfamide substitués par un tétrahydroisoquinoléine, des procédés permettant de préparer ces composés, des compositions pharmaceutiques comprenant lesdits composés ainsi que leur utilisation pour traiter et prévenir une maladie, telle que des troubles CNS, dans laquelle 5-HT est impliqué.

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