5-ht7 receptor antagonists

Details 5-ht7 receptor antagonists 5-ht7 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 221/16 (2006.01) A61K 31/473 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2591201

The invention relates to compounds of structure (I) having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5- tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

L'invention concerne des composés de structure (I) présentant une activité pharmacologique envers le récepteur 5-HT7, et plus particulièrement certains composés sulfonamide substitués par le 2,2a,4,5-tétrahydro-1H-3-aza-acénaphtylène. L'invention décrit également des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant, et leur utilisation pour le traitement et/ou la prophylaxie d'une maladie dans laquelle 5-HT est impliquée, telle que les troubles du système nerveux central.

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