5-hydroxypyrimidine-4-carboxamide compound

Details 5-hydroxypyrimidine-4-carboxamide compound 5-hydroxypyrimidine-4-carboxamide compound

C - Chemistry, Metallurgy

07

D

C07D 239/34 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 7/06 (2006.01) A61P 43/00 (2006.01) C07D 239/56 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2722028

The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: (see formula 1) [wherein, R1 represents a group -X-Q1, X-Q1-Y Q2 or -X-Q1-Y Q2-Z-Q3, X represents a single bond, -CH2- or the like, Q1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, -CH2-, or the like, Q2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, -CR11R12- or the like, R11 and R12 each independently represents a hydrogen atom, a halogen atom or the like, Q3 represents a phenyl group which may have substituent(s), a C3-C7 cycloalkyl group which may have substituent(s), a C3-C7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R2 represents a C1-C3 alkyl group or the like, and R3 represents a hydrogen atom or a methyl group].

L'invention concerne un composé représenté par la formule générale (1) ou un sel pharmaceutiquement acceptable de celui-ci, qui peut favoriser la production d'érythropoïétine. [Dans la formule (1), R1 représente un groupe représenté par -X-Q1, -X-Q1-Y-Q2 ou -X-Q1-Y-Q2-Z-Q3; X représente une liaison unique, -CH2- ou similaire; Q1 représente un groupe hydrocarbure monocyclique ou bicyclique qui peut posséder un substituant; Y représente une liaison unique, -CH2- ou similaire; Q2 représente un groupe à cycle hydrocarbure monocyclique ou bicyclique qui peut posséder un substituant ou similaire; Z représente une liaison unique, -CH2- ou similaire; Q3 représente un groupe phényle qui peut posséder un substituant ou similaire; R2 représente un groupe alkyle en C1-C3 ou similaire; et R3 représente un atome d'hydrogène ou similaire.]

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