C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/08 (2006.01) C07D 209/04 (2006.01) C07D 403/02 (2006.01)
Patent
CA 2702798
Described herein are methods for the synthesis of 3-[5-(pyridin-2-ylmethoxy)-3- (2-methyl-2-propylthio)-1-[4-(2- methoxypyridin-5-yl)benzyl]-indol-2-yl]-2,2-dimethyl-propionic acid, pharmaceutically acceptable salts, pharmaceutically acceptable solvates thereof. Also described are pharmaceutical compositions suitable for oral administration to a mammal, as well as methods of using such oral pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.
La présente invention concerne des procédés permettant de réaliser la synthèse du 3-[5-(pyridin-2-ylméthoxy)-3-(2-méthyle-2-propylthio)-1-[4-(2-méthoxypyridin-5-yle)benzyle]-indol-2-yle]-2,2-diméthyle-acide propionique, des sels pharmaceutiquement acceptables et des solvates pharmaceutiquement acceptables de ceux-ci. La présente invention concerne également des compositions pharmaceutiques adaptées pour être administrées par voie orale à un mammifère. L'invention porte en outre sur des procédés d'utilisation de ces compositions pharmaceutiques orales dans le traitement de maladies ou d'états respiratoires ainsi que d'autres maladies ou états induits par le leucotriène ou dépendants du leucotriène.
Evans Jillian F.
Hutchinson John Howard
King Christopher David
Prasit Petpiboon Peppi
Rewolinski Melissa Virginia
Amira Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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