C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/26 (2006.01) C07D 209/04 (2006.01)
Patent
CA 2686232
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
La présente invention concerne des composés et des compositions pharmaceutiques contenant de telles compositions, qui modulent l'activité de la protéine FLAP (5-Lipoxygenase-Activating Protein = protéine activant la 5-lipoxygénase). L'invention concerne également des procédés pour l'utilisation de tels modulateurs de la FLAP, seuls ou en association avec d'autres composés, pour le traitement d'états ou d'affections respiratoires, cardiovasculaires, ou autrement dépendants des leukotriènes ou découlant d'une médiation par les leukotriènes.
Arruda Jeannie M.
Evans Jillian F.
Haddach Mustapha
Hutchinson John Howard
Li Yiwei
Amira Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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