5-lipoxygenase-activating protein (flap) inhibitors

Details 5-lipoxygenase-activating protein (flap) inhibitors 5-lipoxygenase-activating protein (flap) inhibitors

C - Chemistry, Metallurgy

07

D

C07D 209/30 (2006.01) A61K 31/404 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) C07D 401/02 (2006.01) C07D 417/10 (2006.01) C12N 9/02 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2628467

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

L'invention concerne des composés et des compositions pharmaceutiques contenant de tels composés, qui permettent de moduler l'activité de la protéine d'activation de la 5-lipoxygénase (FLAP). Cette invention a aussi pour objet des méthodes d'utilisation de modulateurs de cette protéine d'activation de la 5-lipoxygénase (FLAP), seuls et en combinaison avec d'autres composés, dans le traitement de troubles ou de maladies respiratoires, cardio-vasculaires et dépendants de la leukotriène ou médiés par la leukotriène.

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