5-lipoxygenase-activating protein inhibitor

Details 5-lipoxygenase-activating protein inhibitor 5-lipoxygenase-activating protein inhibitor

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/437 (2006.01) A61P 11/06 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2724726

Described herein is the FLAP inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy- pyridin-3-yl)-benzyl]-5-(5-methyl- pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of preparing the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, including solvates, and polymorphs thereof. Also described herein are pharmaceutical compositions suitable for administration to a mammal that include the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, and methods of using such pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.

Cette invention concerne lacide 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-méthyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-diméthyl-propionique, qui est un inhibiteur de la FLAP, ou un sel de qualité pharmaceutique de ce composé. Linvention concerne également des méthodes dobtention de linhibiteur FLAP, ou un sel de qualité pharmaceutique, dont des solvates, et des polymorphes dudit inhibiteur. Sont également décrites des compositions pouvant être administrées à un mammifère, qui renferment linhibiteur de la FLAP ou un sel de qualité pharmaceutique de cet inhibiteur, ainsi que des méthodes dutilisation de telles compositions pharmaceutiques pour le traitement daffections ou de maladies respiratoires ainsi que détats pathologiques affections et maladies dépendantes dun leucotriène ou induite par un leucotriène.

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