5-membered heteroaryl substituted 1,4-dihydropyridine...

Details 5-membered heteroaryl substituted 1,4-dihydropyridine... 5-membered heteroaryl substituted 1,4-dihydropyridine...

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2327925

This invention provides a compound of the formula (I): Image or the pharmaceutically acceptable salts thereof wherein A is independently halo; Y1 is -(CH2)m-, C(O) or S(O); Y2 is N or CH; R1 and R2 are independently C1-4 alkyl; R3 is selected from the following: (a) optionally substituted -(CH2)p C3-7, cycloalkyl; (b) optionally substituted -Cue, alkyl; and (c) substituted -C1-4 alkyl; and (d) optionally substituted C7-9 bicycloalkyl; R4 is optionally substituted thiazolyl, imidazolyl or oxazolyl; X is S, -NH, - N-C1-4 alkyl or O; R5 is hydrogen or C1-4 alkyl; R6 is C1-4 alkyl or halo; m is 0, 1 or 2;n is 0, 1, 2, 3, 4 or 5; and p is 0, 1, 2, 3, 4, 5 or 6. These compounds are useful for the treatment of medical conditions mediated by bradykinin such as inflammation, allergic rhinitis, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.

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