5-membered heterocycle-based p38 kinase inhibitors

Details 5-membered heterocycle-based p38 kinase inhibitors 5-membered heterocycle-based p38 kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/38 (2006.01) A61K 31/415 (2006.01) A61P 29/00 (2006.01) C07D 233/88 (2006.01) C07D 405/10 (2006.01)

Patent

CA 2526455

Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38.alpha. and p38.beta. kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including method of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

L'invention concerne des inhibiteurs de la kinase p38 à base d'hétérocycles à 5 chaînons. L'invention concerne en outre des inhibiteurs de la kinase p38, notamment de la kinase p38.alpha. et p38.beta., à base de pyrazoles et d'imidazoles. L'invention concerne par ailleurs des compositions pharmaceutiques contenant ces composés, ainsi que des méthodes d'utilisation de ces composés et de ces compositions, notamment des méthodes visant à traiter, prévenir ou améliorer un ou plusieurs symptômes de maladies et de troubles à médiation par la kinase p38 comprenant, de façon non limitative, des maladies et des troubles inflammatoires.

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