C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/28 (2006.01) A61K 31/33 (2006.01) A61P 43/00 (2006.01) C07D 233/50 (2006.01) C07D 233/54 (2006.01) C07D 263/32 (2006.01) C07D 277/34 (2006.01) C07D 401/06 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2443403
The invention relates to thiazole, oxazole or imidazole derivatives having at least one of the following pharmacological activities: inhibition of monoamine oxidases (MAO); inhibition of lipid peroxidation; modulation of sodium channels. The inventive compounds comprise, for example, 2,6-ditert-butyl-4-{2-[2-(methylamino)ethyl]-1,3-thiazol-4-yl}phenol; et le 2-[4-(1,1'-biphenyl-4-yl)-1H-imidazol-2-yl]ethylcarbamate de 4-methylpenty l. By virtue of their pharmacological properties, said compounds can be used to treat one of the following disorders or diseases: Parkinson's disease, senile dementia, Alzheimer's disease, Huntington's chorea, amyotrophic lateral sclerosis, schizophrenia, depression, psychoses, migraine or pain, especially neuropathic pain.
L'invention concerne des dérivés de thiazoles, d'oxazoles ou d'imidazoles ayant au moins l'une des activités pharmacologiques suivantes: inhibition des monoamine oxydases (MAO); inhibition de la peroxydation lipidique; modulation des canaux sodiques. Ces composés comprenant par exemple: - le 2,6-ditert- butyl-4-{2-[2-(méthylamino)éthyl]-1,3-thiazol-4-yl}phénol; et le 2-[4-(1,1'- biphényl-4-yl)-1H-imidazol-2-yl]éthylcarbamate de 4-méthylpentyle. Du fait de leurs propriétés pharmacologiques, lesdits composés peuvent notamment être utilisés pour à traiter l'un des désordres ou l'une des maladies suivantes: la maladie de Parkinson, les démences séniles, la maladie d'Alzheimer, la chorée de Huntington, la sclérose latérale amyotrophique, la schizophrénie, les dépressions, les psychoses, la migraine ou les douleurs et en particulier les douleurs neuropathiques.
Bigg Dennis
Harnett Jeremiah
Liberatore Anne-Marie
Rolland Alain
Goudreau Gage Dubuc
Ipsen Pharma S.a.s
Societe de Conseils de Recherches Et D'applications Scientifique
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