5-membered heterocyclic amides and related compounds

Details 5-membered heterocyclic amides and related compounds 5-membered heterocyclic amides and related compounds

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/415 (2006.01) A61K 31/426 (2006.01) A61K 31/506 (2006.01) C07D 231/14 (2006.01) C07D 333/40 (2006.01) C07D 401/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2691507

5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des amides hétérocycliques à 5 chaînons et des composés associés, de Formule :, dans laquelle les variables sont telles que définies dans la description. Les composés selon l'invention sont des ligands pouvant servir à moduler une activité de récepteur spécifique in vivo ou in vitro, et ils sont particulièrement utiles dans le traitement d'affections associées à une activation pathologique de récepteurs chez des humains, des animaux de compagnie et des animaux d'élevage. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces composés dans le traitement de ces troubles, ainsi que des méthodes d'utilisation de ces ligands dans des études de localisation de récepteurs.

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