5-methyl-1-(substituted phenyl)-2-(1h)-pyridone in the...

Details 5-methyl-1-(substituted phenyl)-2-(1h)-pyridone in the... 5-methyl-1-(substituted phenyl)-2-(1h)-pyridone in the...

A - Human Necessities

61

K

A61K 31/4412 (2006.01) A61K 31/4418 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2603763

The use of 1-(substituted phenyl )-5-methyl-2-(1H) pyridone in the manufacture of medicaments for treating fibrosis in organs or tissues . It indicates that 1-(substituted phenyl )-5-methyl-2-(1H) pyridone can inhibit the cells produced by various ECM , and their effect is higher than pirfenidone . Therefore, this tpye of compounds can be used as active ingredient for preparing the antifibrotic agent in organs and tissues.

La présente invention a pour objet l'utilisation de 5-méthyl-2-(1H)-pyridone substituée en 1 par un groupement phényle dans la fabrication de médicaments pour le traitement de la fibrose d'organes ou de tissus. Elle montre qu~une 5-méthyl-2-(1H)-pyridone substituée en 1 par un groupement phényle est susceptible d'inhiber les cellules produites par diverses matrices extra-cellulaires (ECM), et que l'effet de telles molécules est plus élevé que celui de la pirfenidone. Ainsi, ce type de composé peut être employé en tant que principe actif dans la préparation d'agent antifibrotique au sein des organes et tissus.

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