5'-modified bicyclic nucleic acid analogs

Details 5'-modified bicyclic nucleic acid analogs 5'-modified bicyclic nucleic acid analogs

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2651453

The present invention provides 5'-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5'-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.

La présente invention concerne des analogues de nucléosides bicycliques modifiés en 5' et des composés oligomères comprenant l'un au moins desdits analogues de nucléosides. Sous des modes de réalisation préférés, le carbone 5' desdits analogues de nucléosides présente une chiralité de type (R) ou (S). De tels analogues de nucléosides bicycliques sont utiles pour renforcer les propriétés de composés oligomères, notamment par exemple la résistance aux nucléases.

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