5-naphthalen-1-yl-1,3-dioxane derivatives, preparation and...

C - Chemistry – Metallurgy – 07 – D

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C07D 319/06 (2006.01) A61K 31/335 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2236265

Compounds of general formula (I), wherein R1 is a hydrogen atom or a (C1-4) alkyl, (C3-6) cycloalkylméthyl or phenyl (C1-3) alkyl group optionally substituted on the phenyl ring by one or more atoms or groups selected from halogens and methyl, trifluoromethyl, methoxy and cyano groups, R2 is a hydroxy or alkoxy group or a group of general formula NR3R4 where each of R3 and R4 is a hydrogen atom, an alkyl group, a cycloalkyl group, a cycloalkylmethyl group, a phenyl group, a phenylmethyl group or a pyridinyl group, or R3 and R4, taken together with the nitrogen atom, form a pyrrolidine or piperidine ring, and n is 1, 2 or 3. The compounds are for therapeutical use.

Composés de formule générale (I), dans laquelle R¿1? représente un atome d'hydrogène ou un groupe (C¿1-4?)alkyle, (C¿3-6?)cycloalkylméthyle ou phényle (C¿1-3?)alkyle éventuellement substitué sur le noyau phényle par un ou plusieurs atomes ou groupes choisis parmi les halogènes et les groupes méthyle, trifluorométhyle, méthoxy et cyano, R¿2? représente un groupe hydroxy ou alcoxy ou un groupe de formule générale NR¿3?R¿4? dans laquelle R¿3? et R¿4?, représentent chacun un atome d'hydrogène, un groupe alkyle, un grope cycloalkyle, un groupe cycloalkylméthyle, un groupe phényle, un groupe phénylméthyle ou un groupe pyridinyle, ou bien R¿3? et R¿4? forment ensemble, avec l'atome d'azote, un cycle pyrrolidine ou pipéridine, et n représente le nombre 1, 2 ou 3. Application en thérapeutique.

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