5-nor-bicyclomycin-5-one derivatives

Details 5-nor-bicyclomycin-5-one derivatives 5-nor-bicyclomycin-5-one derivatives

C - Chemistry, Metallurgy

07

D

260/237.7

C07D 498/08 (2006.01) C07H 9/06 (2006.01)

Patent

CA 1089457

Abstract of the Disclosure Derivatives of 5-norbicyclomycin of the formula Image wherein R represents an unsubstituted or substituted mono- valent hydrocarbon radical in which one, two or more carbon atoms can be replaced by heteroatoms, and X represents a bi- valent group of the formula -O- or -N(R')-, wherein R' has one of the meanings assigned to R, whilst R and R', if both have a meaning which is different from hydrogen, can also be linked to each other through a C-C bond or an oxygen, sulphur or nitrogen atom, and corresponding compounds, in which at least one hydroxyl group is protected, and salts of said compounds, provided they contain salt-forming groups, are useful as anti- biotics, especially against Enterobacteriaceae, or as inter- mediates for the production of such antibiotics. They are obtained by condensing a corresponding 5-norbicyclomycin-5-one with a compound of the formula R-X-NH2 in which X and R have the above meaning.

278748

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