C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/438 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2737740
The present invention is directed to novel 5-oxazolidin-2-one substituted 1, 3,8 -thazaspiro [4.5 ]decan-4 -one derivatives useful in the treatment of disorders and conditions mediated by the ORL-1 receptor. The present invention is further directed to processes for the preparation of said derivatives, pharmaceutical compositions comprising said derivatives and methods for the treatment of ORL-1 mediated disorders and conditions.
La présente invention concerne des dérivés inédits de 1,3,8-triazaspiro[4.5]décan-4-one substitués par de la 5-oxazolidin-2-one, utilisables dans le cadre du traitement de troubles et d'affections à médiation par le récepteur ORL-1. La présente invention concerne, en outre, des procédés de préparation desdits dérivés, des compositions pharmaceutiques contenant lesdits dérivés et des procédés de traitement de troubles et d'affections à médiation par le récepteur ORL-1.
Battista Kathleen
Bignan Gilles
Connolly Peter J.
Morgan Ross Tina
Janssen Pharmaceutica Nv
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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