5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms...

Details 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms... 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2622725

The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula (I) or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W, A, Y, Z, R101 and R200 are described in the specification.

L'invention concerne le besoin actuel d'inhibiteurs sélectifs et puissants de la protéine tyrosine kinase qui consiste à fournir des inhibiteurs puissants de kinase C-FMS. L'invention concerne les nouveaux composés de la formule I; ou un solvate, un hydrate, un tautomère ou un sel pharmaceutiquement acceptable de ceux-ci. W, A, Y, Z, R101 et R200 sont précisés dans le descriptif.

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