5-oxygenated-2,4,6-triaminopyrimidines

Details 5-oxygenated-2,4,6-triaminopyrimidines 5-oxygenated-2,4,6-triaminopyrimidines

C - Chemistry, Metallurgy

07

J

C07J 43/00 (2006.01) C07D 239/50 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2071000

2071000 9111453 PCTABS00006 The present invention discloses 5-oxygenated amino substituted pyrimidines (X), where R1 is (1) steroid substituent of formula (Steroid), (2) trolox substituent of formula (trolox), (3) an alkyl substituent selected from the group consisting of (A)Q2-(CH2)n2. Also disclosed are the oxygenated N,N-disubstituted pyrimidines (XIII) all of which are useful for treating a number of conditions including head injury, stroke, spinal cord injury, etc. Useful intermediates including the protected 5-oxygenated pyrimidines (VII) and the 5-oxygenated pyrimidines (VIII) are also disclosed. Further disclosed are 5-hydroxy amino substituted pyrimidines (XI).

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