5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives

Details 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives

C - Chemistry, Metallurgy

07

D

167/218, 260/251

C07D 239/04 (2006.01) A61K 31/505 (2006.01) C07D 239/06 (2006.01)

Patent

CA 1273016

PATENT APPLICATION entitled: 5-Phenyl-1,4,5,6-tetrahydropyrimidine derivatives in the name of: Société anonyme dite: LABORATOIRE L. LAFON inventor: Louis LAFON ABSTRACT OF THE DISCLOSURE The present invention relates to new deriva- tives selected from the group comprising: (i) the 5-phenylhydropyrimidines of the formula: Image (I) in which: X1 and X2, which are identical or different, each represent H, F, Cl, Br or CF3, and A represents a polyhydropyrimidinyl group of the structure Image or Image in which: Y represents H or OH, Ra represents a C1-C4 alkyl group or a C2-C5 alkanoyl group, it being possible for Ra to represent the hydrogen atom when at least one of the groups X1, X2 and Y is different from H, Rb represents a C1-C3 alkyl group, and R? and R?, which are identical. or different, each represent the hydrogen atom or a C1-C3 alkyl group; and (ii) their addition salts. The said derivatives are useful as pharma- ceuticals.

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