C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 260/291
C07D 211/80 (2006.01) C07D 211/84 (2006.01) C07D 211/90 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 1296731
ABSTRACT 5-Aryl-1,4-dihydropyridines of the formula Image in which R - represents cycloalkyl, - heteroaryl or - aryl which is optionally substituted by at least one sub- stituent independently selected from the group consisting of halogen, nitro, hydroxyl, amino, carboxyl, alkoxycarbonyl, cyano, acyl, acyloxy, acylthio, by alkyl, alkyloxy, alkylthio or alkylsulphonyl, each of which is optionally substituted by one or more halogens, by aryl which is optionally substituted by alkyl, alkoxy, halogen or nitro, or optionally by the group -Z-CH2-R4 where Z - represents oxygen or sulphur, and R4 - represents cycloalkyl, - heteroaryl or - aryl which is optionally substituted by halogen, cyano, nitro, hydroxyl, carboxyl, alkoxycarbonyl or by alkyl or alkoxy, each of which is optionally substituted by one or more halogens, R1 and R2 - are identical or different and - represent straight-chain or branched alkyl which is optionally substituted by aryl, carboxyl, alkoxycarbonyl or by hydroxyl, R3 - represents nitro, cyano or - the group -?-A-R5, where A - represents oxygen, sulphur or -N-R6, R6 - represents hydrogen, phenyl or alkyl, and where R5 - represents hydrogen, - cycloalkyl or - a hydrocarbon radical which is optionally interrupted in the chain by one or more carbonyl groups and/or sulphur and/or oxygen atoms and is optionally substituted by halogen, nitro, cyano, hydroxyl, mercapto, carboxyl, alkoxycarbonyl, aryl, acyloxy, acylthio, heteroaryl or by an amino group, the amino group carrying one or two identical or different substituents from the group comprising phenyl, alkyl or aralkyl, X and Y- are indentical or different and - represent hydrogen, - alkyl, alkoxy or alkoxycarbonyl, - halogen, hydroxyl, nitro, carboxyl, cyano or - trifluoromethyl or trifluoromethoxy, or physiologically acceptable salts thereof, are active on the cardiovascular system.
499875
Gross Rainer
Kayser Michael
Pelster Bernd
Schramm Matthias
Stoltefuss Jurgen
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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