5-phenyl-1h-3-benzazepine derivatives

Details 5-phenyl-1h-3-benzazepine derivatives 5-phenyl-1h-3-benzazepine derivatives

C - Chemistry, Metallurgy

07

D

260/241.15, 260/

C07D 223/16 (2006.01) C07D 403/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1091665

IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS Abstract of the disclosure Compounds of formula I, Image I wherein either R1 is hydrogen, halogen, trifluoromethyl or lower alkyl or alkoxy, and R2 is hydrogen or lower alkoxy , or R1 and R2 together are methylenedioxy, R3 is hydrogen, halogen, trifluoromethyl, lower alkyl or alkoxy or alkylsulphonyl, R4 is hydrogen, halogen, lower alkyl or alkoxy, and either (i) R5 is hydrogen, lower alkyl or hydroxy- alkyl, lower alkyl mono-substituted by cycloalkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, lower alkenyl or alkynyl, wherein the multiple bond is in other than the .alpha.,.beta.-position, or phenylalkyl of 7 to 10 carbon atoms, and R6 is hydrogen, lower alkyl or hydroxy- alkyl, or (ii) R5 and R6 together with the nitrogen atom to which they are bound are 1-piperidi- nyl, 1-pyrrolidinyl, 1-morpholinyl, 1- piperazinyl or 1-(4-lower alkyl)-pipera- zinyl are useful as anti-aggressives and anti-depressives.

303796

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