5-phenyl-1h-pyrazol-4-propionic acid derivatives their...

Details 5-phenyl-1h-pyrazol-4-propionic acid derivatives their... 5-phenyl-1h-pyrazol-4-propionic acid derivatives their...

C - Chemistry, Metallurgy

07

D

167/238, 260/315

C07D 231/12 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2037559

- 27 - ABSTRACT Compounds of formula I Image (I) wherein R1 is alkyl, alkoxy, alkylthio, alkylamino, aryl, aryl- oxy, arylthio, arylamino, aralkyl, aralkoxy, aralkyl- thio or aralkylamino, R2 and R3 are each independently hydrogen, halogen, hydroxy, mercapto, nitro or amino or have the meanings given for R1, and X is -NH2, -NH-OH, -N(R4)OH, -NH-NH2 or -NH-N=C(R4)R5, wherein R4 and R5 are each alkyl, in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular in the treatment or prophylaxis of asthma, or in the treatment of inflammation or psoriasis.

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