5-phenyl-3-pyridazinone derivatives and drug compositions...

Details 5-phenyl-3-pyridazinone derivatives and drug compositions... 5-phenyl-3-pyridazinone derivatives and drug compositions...

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01) A61K 31/50 (2006.01) C07D 401/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2257142

5-Phenyl-3-pyridazinone derivatives represented by general formula (I) wherein R1 is optionally substituted C1-C8 alkyl, C3-C7 cycloalkyl, or indanyl; R2 is C1-C4 alkyl; R3 is hydrogen, optionally substituted C1-C5 alkyl, C3-C7 cycloalkyl or aryl optionally containing a hetero atom; R4 and R5 are each independently hydrogen, C1-C6 alkyl, optionally substituted phenyl, or monocyclic aryl containing a hetero atom; and the broken line refers to a single or double bond, with the proviso that when the line refers to the former, R6 is hydrogen or C1-C6 alkyl.

Dérivés de 5-phényle-3-pyridazinone représentés par la formule (I) dans laquelle R¿1? représente alkyle C¿1?-C¿8? éventuellement substitué, cycloalkyle C¿3?-C¿7? ou indanyle; R¿2? représente alkyle C¿1?-C¿4?; R¿3? représente hydrogène, alkyle C¿1?-C¿5? éventuellement substitué, cycloalkyle C¿3?-C¿7? ou aryle contenant éventuellement un hétéroatome; R¿4? et R¿5? représentent chacun indépendamment hydrogène, alkyle C¿1?-C¿6?, phényle éventuellement substitué ou aryle monocyclique contenant un hétéroatome; la ligne brisée représente une liaison simple ou double, à condition que quand la ligne représente une liaison simple, R¿6? représente hydrogène ou alkyle C¿1?-C¿6?.

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