5-phenyl-5,6,7,8-hydroquinoline tachykinin receptor antagonists

Details 5-phenyl-5,6,7,8-hydroquinoline tachykinin receptor antagonists 5-phenyl-5,6,7,8-hydroquinoline tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 215/00 (2006.01) C07D 215/16 (2006.01)

Patent

CA 2589577

The present invention is directed to certain 5-phenyl-5,6,7,8-hydroquinoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

L'invention concerne certains composés 5-phényl-5,6,7,8-hydroquinoline utiles en tant qu'antagonistes des récepteurs de la neurokinine-1 (NK-1), et inhibiteurs de la tachykinine, en particulier de la substance P. L'invention concerne également des préparations pharmaceutiques contenant ces composés comme principes actifs, ainsi que l'utilisation desdits composés et préparations dans le traitement de certains troubles, notamment le vomissement, l'incontinence urinaire, la dépression et l'anxiété.

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