5-phenyl-isoxazole-3-carboxamide derivatives as trpv1...

Details 5-phenyl-isoxazole-3-carboxamide derivatives as trpv1... 5-phenyl-isoxazole-3-carboxamide derivatives as trpv1...

C - Chemistry, Metallurgy

07

D

C07D 261/14 (2006.01) A61K 31/4155 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2694663

The present invention relates to isoxazole-3-carboxamide derivative having the general Formula (I), or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3- carboxamide derivatives for the treatment of TRPV 1 mediated disorders, such as acute and chronic pain disorders, acute and chronic neuropathic pain, acute and chronic inflammatory pain, respiratory diseases, and lower urinary tract disorders.

L'invention se rapporte à un dérivé d'isoxazole-3-carboxamide répondant à la formule générale (I) ou un sel pharmaceutiquement acceptable de ce dernier, à des compositions pharmaceutiques le renfermant et à l'utilisation desdits dérivés d'isoxazole-3-carboxamide dans le traitement de troubles médiés par TRPV1, tels que les troubles liés à la douleur aiguë et chronique, la douleur neuropathique aiguë et chronique, la douleur inflammatoire aiguë et chronique, les maladies respiratoires et les troubles des voies urinaires inférieures.

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