5-phenyl-isoxazole-3-carboxamides modulating hsp90 with...

Details 5-phenyl-isoxazole-3-carboxamides modulating hsp90 with... 5-phenyl-isoxazole-3-carboxamides modulating hsp90 with...

C - Chemistry, Metallurgy

07

D

C07D 261/18 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/5025 (2006.01) A61P 23/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 413/12 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2729710

The present invention relates to formula I compounds having antitumoural activities through, as one possible biological target, the molecular chaperone heat shock protein 90 (Hsp90) inhibition. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of Hsp90 is responsive, and the pharmaceutical compositions containing such compounds.

La présente invention concerne des composés de formule I ayant des activités antitumorales par, en tant que cible biologique possible, linhibition de la protéine chaperon moléculaire de choc thermique 90 (Hsp90). Linvention comprend lutilisation de tels composés en médecine, en relation avec une maladie cancéreuse ainsi que dautres maladies pour lesquelles une inhibition de Hsp90 est efficace, et les compositions pharmaceutiques contenant de tels composés.

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