5-(pyridinyl)-1h-benzimadazol-2-ols,-2-thiols, their alkyl...

Details 5-(pyridinyl)-1h-benzimadazol-2-ols,-2-thiols, their alkyl... 5-(pyridinyl)-1h-benzimadazol-2-ols,-2-thiols, their alkyl...

C - Chemistry, Metallurgy

07

D

260/280, 260/277

C07D 401/02 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01)

Patent

CA 1180714

ABSTRACT OF THE DISCLOSURE 5-(Py-Y)-1H-benzimidazol-2-ol or 5-(Py-Y)-1H-ben- zimidazole-2-thiol or lower-alkyl ethers or thioethers thereof or pharmaceutically-acceptable acid-addition salts thereof, useful as cardiotonics, are prepared by reacting 4- (Py-Y)-1,2-benzenediamine with urea or carbonyldiimidazole to produce 5-(Py-Y)-1H-benzimidazol-2-ol or with thiourea, an alkali metal lower-alkyl xanthate or thiocarbonyldi- imidazole to produce 5-(Py-Y)-1H-benzimidazole-2-thiol and by reacting 5-(Py-Y)-1H-benzimidazole-2-thiol with a lower- alkylating agent to produce 2-(lower-alkylthio)-5-(Py-Y)-1H- benzimidazole. 2-(Lower-alkoxy)-5-(Py-Y)-1H-benzimidazole is prepared by reacting 4-(Py-Y)-1,2-benzenediamine with tetra-(lower-alkoxy)methane.

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