5-(pyridinyl)pyridine-2,3-diamines, 5-...

Details 5-(pyridinyl)pyridine-2,3-diamines, 5-... 5-(pyridinyl)pyridine-2,3-diamines, 5-...

C - Chemistry, Metallurgy

07

D

260/246.4, 260/2

C07D 213/72 (2006.01) C07D 213/50 (2006.01) C07D 213/61 (2006.01) C07D 213/64 (2006.01) C07D 213/73 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 213/77 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 213/85 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1171856

ABSTRACT OF THE DISCLOSURE 2-R3RN-3-R1R'N-5-PY-6-Q-pyridines (I) or pharmaceutically-acceptable acid-addition salts thereof are useful as intermediates in the preparation of 1- or 3-substituted-1,3-dihydro-5-Q-6-PY-2H-imidazo[4,5-b]pyridin-2-ones or -2-thionos and also as intermediates for preparing 1- or 3-suhstituted-5-Q- 6-PY-3H(or 1H)-imidazo [4,5-b] pyridines, where Q, R and R' are each hydrogen or (C1-C6)-alkyl, P.gamma. is 4- or 3-pyridilyl or 4- or 3-pyridinyl having one or two (C1-C6)-alkyl substituents, R1 and R3 are each hydrogen, (C1-C6)-alkyl, (C2-C6)-hydroxyalkyl wherein at least two carbon atoms separate the hydroxyl and the connecting linkage, 2,3-dihydroxypropyl, (C3-C6)-alkoxy-alky- wherein at least two carbon atoms separate the oxygen atom and the connect- ing linkage or Y-NB where .gamma. is (C2-C6)-alkylene having at least two carbon atoms is between it connecting linkages and NB is di- [(C1-C6)-alkyl] amino or 4-morpholinyl, Also shown are processes for preparing I and the following intermediates used therein: 2-halo-3-nitro-5-PY-6-Q-pyridines (III), 2-R3RN- 3-nitro-5-P.gamma.-6-Q-pyridines (V), 2-halo-5-P.gamma.-6-Q-pyridines (VII), 2-R3RN-5- P.gamma.-6-Q-pyridines (VIII) and 2-R3RN-3-halo-5-P.gamma.-6-Q-pyridines (IX) or salts thereof, Certain 3-nitro-5-P.gamma.-6-Q-(1H)-pyridinones and 2-R3RN-5-P.gamma.-6-Q- pyridines also are useful as cardiotonics and are shown as active components of cardiac compositions and methods for increasing cardiac contractility.

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